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1. 发明申请

WO2011080631A2 HIGH INTENSITY FOCUSED ULTRASOUND TRANSDUCER OPTIMIZATION 审中-公开
标题翻译：高强度聚焦超声换能器优化
公开(公告)号：WO2011080631A2
公开(公告)日：2011-07-07
申请号：PCT/IB2010/055640
申请日：2010-12-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , RADULESCU, Emil, G. , EHNHOLM, Gosta, Jakob , ERKAMP, Ramon, Q. , KOSKELA, I., A., Julius , SOKKA, Shunmugavelu, D. , VAHALA, Erkki, T. , KOHLER, Max, Oskar
发明人： RADULESCU, Emil, G. , EHNHOLM, Gosta, Jakob , ERKAMP, Ramon, Q. , KOSKELA, I., A., Julius , SOKKA, Shunmugavelu, D. , VAHALA, Erkki, T. , KOHLER, Max, Oskar
IPC分类号： A61N7/00 , A61N7/02 , A61B19/00
CPC分类号： A61N7/02 , A61B2034/104 , A61B2034/105 , A61B2090/374 , A61N2007/0065 , A61N2007/0078 , A61N2007/0095
摘要： When planning magnetic resonance (MR) guided high intensity focused ultrasonic (HIFU) therapy, HIFU transducer element parameters are optimized as a function of 3D MR data describing a size, shape, and position of a region of interest (ROI) (146) and any obstructions (144) between the HIFU transducer elements and the ROI (146). Transducer element phases and amplitudes are adjusted to maximize HIFU radiation delivery to the ROI (146) while minimizing delivery to the obstruction (144). Additionally or alternatively, transducer elements are selectively deactivated if the obstruction (144) is positioned between the ROI (146) and a given transducer element.
摘要翻译：当规划磁共振（MR）引导的高强度聚焦超声波（HIFU）疗法时，HIFU换能器元件参数根据3D MR数据进行优化，所述3D MR数据描述区域的大小，形状和位置兴趣（ROI）（146）以及HIFU换能器元件和ROI（146）之间的任何障碍物（144）。传感器元件的相位和幅度被调整以最大化HIFU辐射传送到ROI（146），同时最小化传送到障碍物（144）。另外或可选地，如果障碍物（144）位于ROI（146）和给定换能器元件之间，则选择性地停用换能器元件。

2. 发明申请

WO2007067200A3 METHOD AND APPARATUS FOR ELASTICITY IMAGING 审中-公开
公开(公告)号：WO2007067200A3
公开(公告)日：2007-06-14
申请号：PCT/US2006/010617
申请日：2006-03-22
申请人： ALOKA CO., LTD. , RADULESCU, Emil, G.
发明人： RADULESCU, Emil, G.
IPC分类号： A61B8/00
摘要： A computational efficient algorithm for compression analysis of free-hand static elasticity imaging performed using medical diagnostic ultrasound imaging equipment offers tissue compression quality and quantity feedback to the operator. The algorithm includes a criterion for automatic selection of the most advantageous pre- and post-compression frame pairs delivering elasticity images of optimal dynamic ranges (DR) and signal-to-noise ratios (SNR) . The use of the algorithm in real time eases operator training and reduces significantly the amount of artifact in the elasticity images while lowering the computational burden.

3. 发明申请

WO2007070408A3 APPARATUS AND METHOD FOR OPTIMIZED SEARCH FOR DISPLACEMENT ESTIMATION IN ELASTICITY IMAGING 审中-公开
标题翻译：用于优化搜索在弹性成像中的位移估计的装置和方法
公开(公告)号：WO2007070408A3
公开(公告)日：2009-04-09
申请号：PCT/US2006046983
申请日：2006-12-11
申请人： ALOKA CO LTD , RADULESCU EMIL G
发明人： RADULESCU EMIL G
IPC分类号： A61B8/00
CPC分类号： A61B8/08 , A61B8/469 , A61B8/485 , G06T7/0016 , G06T7/238 , G06T2207/30024 , G06T2207/30068 , G06T2207/30241
摘要： A displacement estimation method is described that limits the exhaustive search for all points in a region of interest of a biological tissue by delivering the axial and lateral displacement maps in two phases. During the first phase, the method executes a limited search to determine axial and lateral displacement estimates for a plurality of locations on at least one axial reference line positioned in the ROI. Non-zero estimates form transition points along the axial reference line where one non-zero transition point value differs from another. During the second phase, the method laterally tracks each, transition point throughout the ROI using block-matching algorithms or correlation methods. The displacement estimations identify a trajectory of the transition point through the ROI and form a displacement map. The plurality of transition point displacement maps are assembled as a complete displacement map. The resultant displacement map is used to form a tissue strain display.
摘要翻译：描述了一种位移估计方法，其通过以两相递送轴向和横向位移图来限制对生物组织的感兴趣区域中的所有点的详尽搜索。在第一阶段期间，该方法执行有限搜索以确定位于ROI中的至少一个轴向参考线上的多个位置的轴向和横向位移估计。非零估计值沿着轴向参考线形成转换点，其中一个非零转换点值与另一个非零转换点值不同。在第二阶段期间，该方法使用块匹配算法或相关方法横向跟踪遍历ROI的每个转换点。位移估计识别通过ROI的转换点的轨迹并形成位移图。多个过渡点位移图被组装成完整位移图。所得位移图用于形成组织应变显示。

4. 发明申请

WO2006065615A1 METHOD AND APPARATUS FOR ELASTICITY IMAGING 审中-公开
标题翻译：用于弹性成像的方法和装置
公开(公告)号：WO2006065615A1
公开(公告)日：2006-06-22
申请号：PCT/US2005/044407
申请日：2005-12-07
申请人： ALOKA CO. LTD. , RADULESCU, Emil, G.
发明人： RADULESCU, Emil, G.
IPC分类号： A61B8/00
CPC分类号： A61B8/485 , A61B8/08 , G01S7/52042 , G01S7/5205 , G01S7/52073 , G01S7/52074 , G01S15/8977
摘要： A computational efficient algorithm (12) for compression analysis of free-hand static elasticity imaging performed using medial diagnostic ultrasound imaging equipment (14) offers tissue compression quality and quantity feedback to the operator. The algorithm (12) includes a criterion for automatic selection of the most advantageous pre- and post-compression frame pairs delivering elasticity images of optimal dynamic ranges (DR) and signal-to -noise ratios (SNR). The use of the algorithm (12) in real time eases operator training and reduces significantly the amount of artifact in the elasticity images while lowering the computational burden.
摘要翻译：使用内侧诊断超声成像设备（14）进行的自由静态弹性成像的压缩分析的计算有效算法（12）向操作者提供组织压缩质量和数量反馈。算法（12）包括用于自动选择最有利的压缩前和后压缩帧对的标准，其提供最佳动态范围（DR）和信噪比（SNR）的弹性图像。使用算法（12）实时简化操作员训练，并显着减少弹性图像中的伪像量，同时降低计算负担。

5. 发明申请

WO2011080631A3 HIGH INTENSITY FOCUSED ULTRASOUND TRANSDUCER OPTIMIZATION 审中-公开
标题翻译：高强度聚焦超声波传感器优化
公开(公告)号：WO2011080631A3
公开(公告)日：2011-11-10
申请号：PCT/IB2010055640
申请日：2010-12-07
申请人： KONINKL PHILIPS ELECTRONICS NV , RADULESCU EMIL G , EHNHOLM GOSTA JAKOB , ERKAMP RAMON Q , KOSKELA I A JULIUS , SOKKA SHUNMUGAVELU D , VAHALA ERKKI T , KOHLER MAX OSKAR
发明人： RADULESCU EMIL G , EHNHOLM GOSTA JAKOB , ERKAMP RAMON Q , KOSKELA I A JULIUS , SOKKA SHUNMUGAVELU D , VAHALA ERKKI T , KOHLER MAX OSKAR
IPC分类号： A61N7/00 , A61B19/00 , A61N7/02
CPC分类号： A61N7/02 , A61B2034/104 , A61B2034/105 , A61B2090/374 , A61N2007/0065 , A61N2007/0078 , A61N2007/0095
摘要： When planning magnetic resonance (MR) guided high intensity focused ultrasonic (HIFU) therapy, HIFU transducer element parameters are optimized as a function of 3D MR data describing a size, shape, and position of a region of interest (ROI) (146) and any obstructions (144) between the HIFU transducer elements and the ROI (146). Transducer element phases and amplitudes are adjusted to maximize HIFU radiation delivery to the ROI (146) while minimizing delivery to the obstruction (144). Additionally or alternatively, transducer elements are selectively deactivated if the obstruction (144) is positioned between the ROI (146) and a given transducer element.
摘要翻译：当计划磁共振（MR）引导的高强度聚焦超声（HIFU）治疗时，HIFU换能器元件参数被优化为描述感兴趣区域（ROI）（146）的尺寸，形状和位置的3D MR数据的函数，并且 HIFU换能器元件和ROI（146）之间的任何障碍物（144）。调节传感器元件相位和振幅以最大化HIFU辐射传递到ROI（146），同时最小化到障碍物的传递（144）。另外或替代地，如果障碍物（144）位于ROI（146）和给定的换能器元件之间，则换能器元件被选择性地停用。

6. 发明申请

WO2007070408A2 APPARATUS AND METHOD FOR OPTIMIZED SEARCH FOR DISPLACEMENT ESTIMATION IN ELASTICITY IMAGING 审中-公开
标题翻译：用于优化搜索在弹性成像中的位移估计的装置和方法
公开(公告)号：WO2007070408A2
公开(公告)日：2007-06-21
申请号：PCT/US2006/046983
申请日：2006-12-11
申请人： ALOKA CO., LTD. , RADULESCU, Emil, G.
发明人： RADULESCU, Emil, G.
IPC分类号： A61B8/00
CPC分类号： A61B8/08 , A61B8/469 , A61B8/485 , G06T7/0016 , G06T7/238 , G06T2207/30024 , G06T2207/30068 , G06T2207/30241
摘要： A displacement estimation method is described that limits the exhaustive search for all points in a region of interest of a biological tissue by delivering the axial and lateral displacement maps in two phases. During the first phase, the method executes a limited search to determine axial and lateral displacement estimates for a plurality of locations on at least one axial reference line positioned in the ROI. Non-zero estimates form transition points along the axial reference line where one non-zero transition point value differs from another. During the second phase, the method laterally tracks each transition point throughout the ROI using block-matching algorithms or correlation methods. The displacement estimations identify a trajectory of the transition point through the ROI and form a displacement map. The plurality of transition point displacement maps are assembled as a complete displacement map. The resultant displacement map is used to form a tissue strain display.
摘要翻译：描述了一种位移估计方法，其通过以两相递送轴向和横向位移图来限制对生物组织的感兴趣区域中的所有点的详尽搜索。在第一阶段期间，该方法执行有限搜索以确定位于ROI中的至少一个轴向参考线上的多个位置的轴向和横向位移估计。非零估计值沿着轴向参考线形成转换点，其中一个非零转换点值与另一个非零转换点值不同。在第二阶段期间，该方法使用块匹配算法或相关方法横向跟踪整个ROI的每个转换点。位移估计识别通过ROI的转换点的轨迹并形成位移图。多个过渡点位移图被组装成完整位移图。所得位移图用于形成组织应变显示。

7. 发明申请

WO2007067200A2 METHOD AND APPARATUS FOR ELASTICITY IMAGING 审中-公开
标题翻译：用于弹性成像的方法和设备
公开(公告)号：WO2007067200A2
公开(公告)日：2007-06-14
申请号：PCT/US2006010617
申请日：2006-03-22
申请人： ALOKA CO LTD , RADULESCU EMIL G
发明人： RADULESCU EMIL G
IPC分类号： A61B8/00
CPC分类号： A61B8/14 , A61B5/0051 , A61B5/0053 , A61B8/08 , A61B8/485 , G01S7/52026 , G01S7/52034 , G01S7/52042 , G01S7/5206
摘要： A computational efficient algorithm for compression analysis of free-hand static elasticity imaging performed using medical diagnostic ultrasound imaging equipment offers tissue compression quality and quantity feedback to the operator. The algorithm includes a criterion for automatic selection of the most advantageous pre- and post-compression frame pairs delivering elasticity images of optimal dynamic ranges (DR) and signal-to-noise ratios (SNR) . The use of the algorithm in real time eases operator training and reduces significantly the amount of artifact in the elasticity images while lowering the computational burden.
摘要翻译：用于使用医疗诊断超声成像设备执行的自由手静态弹性成像的压缩分析的计算高效算法向操作者提供组织压缩质量和数量反馈。该算法包括用于自动选择最有利的预压缩帧对和后压缩帧对的标准，其传送最佳动态范围（DR）和信噪比（SNR）的弹性图像。该算法的实时使用简化了操作员训练，并显着减少了弹性图像中的伪影数量，同时降低了计算负担。

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